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Prefrin Liquifilm: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Prefrin Liquifilm - General Information

An alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent. [PubChem]

 

Pharmacology of Prefrin Liquifilm

Prefrin Liquifilm is a powerful vasoconstrictor. It is used as a mydriatic, nasal decongestant, and cardiotonic agent. Prefrin Liquifilm is a postsynaptic alpha-receptor stimulant with little effect on the beta receptors of the heart. Parenteral administration of Prefrin Liquifilm causes a rise in systolic and diastolic pressures, cardiac output is slightly decreased and peripheral resistance is considerably increased, most vascular beds are constricted; renal, splanchnic, cutaneous, and limb blood flows are reduced but coronary blood flow is increased. Pulmonary vessels are constricted, and pulmonary arterial pressure is raised. This alpha receptor sympathetic agonist is also used locally because its vasoconstrictor and mydriatic action.

 

Prefrin Liquifilm for patients

 

Prefrin Liquifilm Interactions

Vasopressors, particularly metaraminol, may cause serious cardiac arrhythmias during halothane anesthesia and therefore should be used only with great caution or not at all.

MAO Inhibitors

The pressor effect of sympathomimetic pressor amines is markedly potentiated in patients receiving monoamine oxidase inhibitors (MAOI). Therefore, when initiating pressor therapy in these patients, the initial dose should be small and used with due caution. The pressor response of adrenergic agents may also be potentiated by tricyclic antidepressants.

 

Prefrin Liquifilm Contraindications

Phenylephrine hydrochloride should not be used in patients with severe hypertension, ventricular tachycardia, or in patients who are hypersensitive to it or to any of the components.

 

Additional information about Prefrin Liquifilm

Prefrin Liquifilm Indication

For the treatment of ophthalmic disorders (hyperaemia of conjunctiva, posterior synechiae, acute atopic), nasal congestion, hemorrhoids, hypotension, shock, hypotension during spinal anesthesia, paroxysmal supraventricular tachycardia. It is also used as an aid in the diagnosis of heart murmurs and for prolongation of spinal anesthesia

Mechanism Of Action
Prefrin Liquifilm produces its ophthalmic and systemic actions by acting on alpha 1 adrenergic receptors in the pupillary dilator muscle and the vascular smooth musle, resulting in contraction of the dilator muscle and contraction of the smooth muscle in the arterioles of the conjunctiva and peripheral vasoconstriction. Prefrin Liquifilm decreases nasal congestion by acting on alpha 1 adrenergic receptors in the arterioles of the nasal mucosa to produce constriction.
Generic Name
Phenylephrine
Synonyms
Fenilefrina [Inn-Spanish]; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; Metaoxedrinum; Metaoxedrine; Metaoxedrin; Metasynephrine; Phenylephrinum [Inn-Latin]
Drug Category
Adrenergic alpha-Agonists; Cardiotonic Agents; Nasal Decongestants; Sympathomimetics; Vasoconstrictor Agents; Mydriatics
Drug Type
Small Molecule; Approved
Other Brand Names containing Phenylephrine
Adrianol; AK-Dilate; AK-Nefrin; Alcon Efrin; Alconefrin Nasal Drops 12; Alconefrin Nasal Drops 25; Alconefrin Nasal Drops 50; Alconefrin Nasal Spray 25; Biomydrin; Dilatair; Dimetane; Dionephrine; Doktors; Duration; I-Phrine; Isophrim; Isophrin; Isopto Frin; M-Sympathol; M-Sympatol; M-Synephrine; Mesaton; Mesatone; Mesatonum; Metasympatol; Metsatonum; Mezaton; Minims Phenylephrine; Mydfrin; Neo-Synephrine; Neo-Synephrine Nasal Drops; Neo-Synephrine Nasal Jelly; Neo-Synephrine Nasal Spray; Neofrin; Neophryn; Neosynephrine; Nostril; Nostril Spray Pump; Nostril Spray Pump Mild; Ocu-Phrin Sterile Eye Drops; Ocugestrin; Phenoptic; Prefrin; Prefrin Liquifilm; Pyracort D; Relief Eye Drops for Red Eyes; Rhinall; Spersaphrine; Vicks Sinex; Visadron;
Absorption
Reduced bioavailability (compared to pseudoephedrine) following oral administration due to significant first-pass metabolism.
Protein Binding
95% binding-plasma proteins
Biotransformation
Oral phenylephrine is extensively metabolised by monoamine oxidase, an enzyme which is present in the stomach and liver.
Half Life
2.1 to 3.4 hours
Dosage Forms of Prefrin Liquifilm
Solution Intravenous
Chemical IUPAC Name
3-[(1R)-1-hydroxy-2-methylaminoethyl]phenol
Chemical Formula
C9H13NO2
Organisms Affected
Humans and other mammals